Centrul Român de Excelență în Neuroștiințe Clinice
PN-IV-P6-6.1-CoEx-2024-0141 (16CoEx / 2026)
The Romanian Centre of Excellence in Neuroscience (NeuRoX) aims to create a first of its kind, platform to harness and integrate cutting-edge technological advancements in neuropathology, genetics/epigenetics, neuro-engineering and artificial intelligence, to unlock new avenues of translational research with measurable positive impact on the diagnosis, prognosis, and treatment of debilitating neurological conditions.
The Centre will also establish the first Romanian neurological tissue, neuro-data and blood bank, and state-of-the-art neural interface design and prototyping hub. Accumulating evidence suggests that the clinical progress of chronic neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Parkinson disease (PD) or Alzheimer’s disease (AD) is better modelled as a continuum, with contributions from concurrent pathophysiological processes that vary across individuals and over time. The prevalence of neuroinflammation, neurovascular unit dysfunction and functional neurodegeneration in these diseases is qualitatively similar (but quantitatively different) and hence, understanding the multidimensional neuromic profile of the specific pathological features combined with deep characterization of concurrent functional processes will unlock novel ways to create improvement in sustainable patient care and quality of life.
The consortium has four pillars: clinical, biological, engineering and advanced bioinformatics. As a partner (P2), Victor Babeș National Institute of Pathology offers advanced nanometer-resolution imaging, genetic analysis and animal studies, crucial for advancing research and treatment of neurological diseases.
-
E