SELECTED PUBLICATIONS (MOST RECENT FIRST):
2024
Dobre A, Nedelcu RI, Turcu G, Brinzea A, Struna I, Tudorache G, Ali A, Hulea I, Balasescu E, Fertig TE, Gherghiceanu M, Harwood C, Ion DA, Forsea AM . Multiple Keratoacanthomas Associated with Genetic Syndromes: Narrative Review and Proposal of a Diagnostic Algorithm. American Journal of Clinical Dermatology 26, 45–59. DOI: 10.1007/s40257-024-00900-0
Tanase A, Andronesi A, Lipan L, Gherghiceanu M, Ismail G. Renal Complications Following Hematopoietic Stem Cell Transplantation. Biochemistry. IntechOpen. DOI: 10.5772/intechopen.1007385.
Balta C, Herman H, Ciceu A, Lepre CC, Mladin B, Rosu M, Oatis D, Russo M, Peteu VE, Gherghiceanu M, Fenyvesi F, Cotoraci C, Trotta MC, D’Amico M, Hermenean A. Chrysin-loaded calixarene-cyclodextrin ternary drug delivery system inhibits TGF-β and galectin-1 mediated pathways in diabetic liver fibrosis. Biochemical Pharmacology 229. DOI: 10.1016/j.bcp.2024.116474.
Obrișcă B, Mocanu V, Jurubiță R, Vrabie A, Berechet A, Lujinschi S, Sorohan B, Andronesi A, Achim C, Lupușoru G, Micu G, Caceaune N, Gherghiceanu M, Ismail G. Histological reappraisal of IgA nephropathy: the role of glomerular pattern of injury and mesangial complement deposition. BMC Nephrology 25, 145. DOI: 10.1186/s12882-024-03577-z.
2023
Obrișcă B, Mocanu V, Vornicu A, Jurubiță R, Sorohan B, Dimofte G, Achim C, Andronesi A, Micu G, Bobeică R, Caceaune N, Procop A, Herlea V, Gherghiceanu M, Ismail G. The impact of SARS-CoV-2 infection on renal function in patients with biopsy-proven kidney diseases. PLOS ONE. DOI: 10.1371/journal.pone.0296168.
Gheorghe RO, Grosu AV, Magercu M, Ghenghea MS, Zbarcea CE, Tanase A, Negres S, Filippi A, Chiritoiu G, Gherghiceanu M, et al. Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain. International Journal of Molecular Sciences. 24(21):15831. DOI: 10.3390/ijms242115831
Balbi C, Parisse P, Vondracek H, Lazzarini E, Bolis S, Fertig TE, Gherghiceanu M, Barile L, Vassalli G. Impact of Isolation Methods on Extracellular Vesicle Functionality In Vitro and In Vivo. Advanced Biology 8(2). DOI: 10.1002/adbi.202300185.
Terinte-Balcan G, Cinca S, Stancu S, Gherghiceanu M, Stefan G. Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum. Ultrastructural Pathology 47(6): 478–483. DOI: 10.1080/01913123.2023.2270030
Pecquet C, Papadopoulos N, Balligand T, Chachoua I, Tisserand A, Vertenoeil G, Nédélec A, Vertommen D, Roy A, Marty C, Nivarthi H, Defour J-P, El-Khoury M, Hug E, Majoros A, Xu E, Zagrijtschuk O, Fertig TE, Marta DS, Gisslinger H, Gisslinger B, Schalling M, Casetti IC, Rumi E, Pietra D, Cavalloni C, Arcaini L, Cazzola M, Komatsu N, Kihara Y, Sunami Y, Edahiro Y, Araki M, Lesyk R, Buxhofer-Ausch V, Heibl S, Pasquier F, Plo I, Vainchenker W, Kralovics R, Constantinescu SN. Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms. Blood 141(8):917-929. DOI: 10.1182/blood.2022016846.
2022
Gharbia S, Nazarie SR, Dinescu S, Balta C, Herman H, Peteu VE, Gherghiceanu M, Hermenean A, Costache M. Adipose-Derived Stem Cells (ADSCs) Supplemented with Hepatocyte Growth Factor (HGF) Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway in Chemical-Induced Liver Fibrosis Associated with Diabetes. Cells 11(21):3338. DOI: 10.3390/cells11213338
Constantin A, Comarița IK, Alexandru N, Filippi A, Bojin F, Gherghiceanu M, Vîlcu A, Nemecz M, Niculescu LS, Păunescu V and Georgescu A. Stem cell‐derived extracellular vesicles reduce the expression of molecules involved in cardiac hypertrophy—In a model of human-induced pluripotent stem cell-derived cardiomyocytes. Frontiers in Pharmacology 13:1003684. DOI: 10.3389/fphar.2022.1003684
Fertig TE, Chitoiu L, Marta DS, Ionescu VS, Cismasiu VB, Radu E, Angheluta G, Dobre M, Serbanescu A, Hinescu ME, Gherghiceanu M. Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination. Biomedicines. DOI: 10.3390/biomedicines10071538.
2021
Balbi C, Milano G, Fertig TE, Lazzarini E, Bolis S, Taniyama Y, Sanada F, Di Silvestre D, Mauri P, Gherghiceanu M, Lüscher TF, Barile L, Vassalli G. An exosomal-carried short periostin isoform induces cardiomyocyte proliferation. Theranostics. DOI:10.7150/thno.57243.
2020
Sorop A, Iacob R, Iacob S, Constantinescu D, Chitoiu L, Fertig TE, Dinischiotu A, Chivu-Economescu M, Bacalbasa N, Savu L, Gheorghe L, Dima S, Popescu I. Plasma Small Extracellular Vesicles Derived miR-21-5p and miR-92a-3p as Potential Biomarkers for Hepatocellular Carcinoma Screening. Frontiers in Genetics. DOI:10.3389/fgene.2020.00712.
2019
Ciullo A, Biemmi V, Milano G, Bolis S, Cervio E, Fertig ET, Gherghiceanu M, Moccetti T, Camici GG, Vassalli G, Barile L. Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration. International Journal of Molecular Sciences. DOI: 10.3390/ijms20030468
Ceafalan LC, Fertig TE, Gheorghe TC, Hinescu ME, Popescu BO, Pahnke J, Gherghiceanu M. Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.13980
2018
Pecquet C, Balligand T, Chachoua I, Roy A, Vertenoeil G, Colau D, Fertig E, Marty C, Nivarthi H, Defour J-P, Xu E, Hug E, Gisslinger H, Gisslinger B, Schalling M, Casetti IC, Rumi E, Pietra D, Cavalloni C, Arcaini L, Cazzola M, Komatsu N, Kihara Y, Sunami Y, Edahiro Y, Araki M, Plo I, Vainchenker W, Kralovics R, Constantinescu SN. Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy. Blood. DOI: 10.1182/blood-2018-99-118348
Barile L, Cervio E, Lionetti V, Milano G, Ciullo A, Biemmi V, Bolis S, Altomare C, Matteucci M, Di Silvestre D, Brambilla F, Fertig TE, Torre T, Demertzis S, Mauri P, Moccetti T, Vassalli G. Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A. Cardiovascular Research. DOI: 10.1093/cvr/cvy055.
2017
Ceafalan LC, Fertig TE, Popescu AC, Popescu BO, Hinescu ME, Gherghiceanu M. Skeletal muscle regeneration involves macrophage-myoblast bonding. Cell Adhesion & Migration. DOI: 10.1080/19336918.2017.1346774
2015
Popescu LM, Curici A, Wang E, Zhang H, Hu S, Gherghiceanu M. Telocytes and putative stem cells in ageing human heart. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.12509
2014
Fertig ET, Gherghiceanu M, Popescu LM. Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.12436
Galiger C, Kostin S, Golec A, Ahlbrecht K, Becker S, Gherghiceanu M, Popescu LM, Morty RE, Seeger W, Voswinckel R. Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung. Journal of Cellular and Molecular Medicine. DOI: 10.1111/jcmm.12295
2012
Barile L, Gherghiceanu M, Popescu LM, Moccetti T, Vassalli G. Ultrastructural Evidence of Exosome Secretion by Progenitor Cells in Adult Mouse Myocardium and Adult Human Cardiospheres. Journal of Biomedicine and Biotechnology. DOI: 10.1155/2012/354605
Gherghiceanu M & Popescu LM. Cardiac telocytes - their junctions and functional implications. Cell and Tissue Research. DOI: 10.1007/s00441-012-1333-8.
2011
Gherghiceanu M, Barad L, Novak A, Reiter I, Itskovitz-Eldor J, Binah O, Popescu LM. Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2011.01417.x
Popescu LM, Gherghiceanu M, Suciu LC, Manole CG, Hinescu ME. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell and Tissue Research. DOI: 10.1007/s00441-011-1229-z
Gherghiceanu M & Popescu LM. Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2011.01299.x
Hinescu ME, Gherghiceanu M, Suciu L, Popescu LM. Telocytes in pleura: two- and three-dimensional imaging by transmission electron microscopy. Cell and Tissue Research. DOI: 10.1007/s00441-010-1095-0
2010
Mandache E, Gherghiceanu M, Macarie C, Kostin S, Popescu LM. Telocytes in human isolated atrial amyloidosis: ultrastructural remodelling. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2010.01200.x
Bani D, Formigli L, Gherghiceanu M, Faussone-Pellegrini MS. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2010.01119.x
Gherghiceanu M, Manole CG, Popescu LM. TELOCYTES IN ENDOCARDIUM: Electron Microscope Evidence. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2010.01133.x
Gherghiceanu M & Popescu LM. Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2010.01060.x
2009
Popescu LM, Gherghiceanu M, Manole CG, Faussone-Pellegrini MS. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2009.00758.x
Gurusamy N, Lekli I, Gorbunov NV, Gherghiceanu M, Popescu LM, Das DK. Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2008.00495.x
2007
Gherghiceanu M & Popescu LM. Electron microscope tomography: further demonstration of nanocontacts between caveolae and smooth muscle sarcoplasmic reticulum. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2007.00166.x
Mandache E, Popescu LM, Gherghiceanu M. Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: shed vesicles as intermediates. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2007.00117.x
Hinescu ME, Ardeleanu C, Gherghiceanu M, Popescu LM. Interstitial Cajal-like cells in human gallbladder. Journal of Molecular Histology. DOI: 10.1007/s10735-007-9099-0
2006
Popescu LM, Gherghiceanu M, Mandache E, Cretoiu D. Caveolae in smooth muscles: nanocontacts. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2006.tb00539.x
Popescu LM, Gherghiceanu M, Hinescu ME, Cretoiu D, Ceafalan L, Regalia T, Popescu AC, Ardeleanu C, Mandache E. Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC). Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2006.tb00410.x
Hinescu ME, Gherghiceanu M, Mandache E, Ciontea SM, Popescu LM. Interstitial Cajal-like cells (ICLC) in atrial myocardium: ultrastructural and immunohistochemical characterization. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2006.tb00306.x
2005
Popescu LM, Gherghiceanu M, Cretoiu D, Radu E. The connective connection: interstitial cells of Cajal (ICC) and ICC-like cells establish synapses with immunoreactive cells. Electron microscope study in situ. Journal of Cellular and Molecular Medicine. DOI: 10.1111/j.1582-4934.2005.tb00502.x
2004
Mandache E & Gherghiceanu M. Ultrastructural defects of the glomerular basement membranes associated with primary glomerular nephropathies. ULTRASTRUCTURAL PATHOLOGY. DOI: 10.1080/01913120490445016