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Development of BIOnanotechnologies based on Extracellular Vesicles for early diagnosis, prognosis and therapy of atherosclerotic disease (BIOVEA)
Various biomarkers have been proposed for the diagnosis and prognosis of acute coronary syndrome, however none for stable coronary disease. Identification of biomarkers that augment established clinical indicators, may allow earlier diagnosis of coronary disease, as well as improved recognition of the risk of complications and cardiovascular death. Additionally, this would pave the way for biomarkers, such as extracellular vesicles, to be employed as precise therapeutic agents in these diseases.
 TEM image of intranuclear polioma virus inclusions (Hârza et al., 2014). |  Stone |  Kidney glomerulus in Fabry disease |  Niemann-Pick disease |
|---|---|---|---|
 LCAT-deficiency |  Tropheryma whipplei |  Glycogenosis |  Cryoglobulinemia |
 Mucopolysaccharidosis |  Amyloidosis |  TEM image showing abnormal mitochondria in cytochrome C oxidase defficiency, likely due to a SCO2 mutation (or a fossilized ichtyosaur if you prefer). |  Paramesangial and mesangial deposits (IgA nephropathy) |
 Crystalline inclusions in a plasmocyte |  "Zebra bodies" (Fabry nephropathy) |  Cholesterol embolus in the vascular pole of a glomerulus |  Mesangial and subendothelial dense deposits (Waldenstrom macroglobulinemia) |
 C3c granular positivity in the glomerulus, in the tubular basement membrane and in the vessels (IFD - lupus nephritis) |  Two glomeruli with massive cellular crescents |  Thrombotic microangiopathy |
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