Development of BIOnanotechnologies based on Extracellular Vesicles for early diagnosis, prognosis and therapy of atherosclerotic disease (BIOVEA)
Various biomarkers have been proposed for the diagnosis and prognosis of acute coronary syndrome, however none for stable coronary disease. Identification of biomarkers that augment established clinical indicators, may allow earlier diagnosis of coronary disease, as well as improved recognition of the risk of complications and cardiovascular death. Additionally, this would pave the way for biomarkers, such as extracellular vesicles, to be employed as precise therapeutic agents in these diseases.
Our research interests lie in the inner workings of cells and how they communicate, through physical contact or over long distances. In recent years, the Ultrastructural Pathology and Bioimaging Lab at Victor Babeș Institute has focused on the morphological characterization and interaction between the different cell types involved in tissue regeneration, however, with the arrival of new, cutting-edge equipment, our interests are now expanding to structural studies at the molecular level.
For this work we are currently funded from a number of national and international grants.
PN-10N/2023-23.16.01.01
Mihaela Gherghiceanu & Mihail Eugen Hinescu
Past projects (2015-2023)
PN-III-P4-ID-PCE2020-2300
Mihaela Gherghiceanu
PN-01N/2019-19.29.01.02
Mihaela Gherghiceanu & Mihail Eugen Hinescu
The molecular architecture of the glomerular basement membrane in immune disorders (NUCLEU)
PN 16.22.03.02
Daciana Silvia Marta
PN-III-P1-1.2-PCCDI-2017-052 / 62PCCDI / 2018
Mihaela Gherghiceanu & Adrian Onu (INC Cantacuzino)
PN-III-P3-3.1-PM-RO-BE-2016-0023
Tudor Emanuel Fertig & Stefan Constantinescu (deDuve Institute, UCL, Belgium)
Involvement of telocytes in regenerative processes
PN 16.22.02.02
Mihaela Gherghiceanu
PN-III-P1-1.2-PCCDI-2017-0527 / 83PCCDI / 2018
Mihaela Gherghiceanu & Adriana Georgescu (IBPC Nicolae Simionescu)
Transport of miRNA by ectosomes in malignant hematologic disorders (NUCLEU)
PN 16.22.01.03
Tudor Emanuel Fertig