The Ultrastructural Pathology and Bioimaging Lab (UPBL) is a research and diagnostic facility of Victor Babeș National Institute of Pathology in Bucharest, Romania, specializing in high-resolution imaging of biological specimens, through a wide array of technologies and methods, from fluorescence to electron microscopy. UPBL currently houses the only super-resolution microscope in Romania (Leica STED3X) and is a Leica Reference Site, organizing workshops for various bioimaging techniques. UPBL is also the first cryo-electron microscopy center in Romania dedicated to life-sciences applications. 
Our facilities and infrastructure are open access to all interested researchers from Romania or abroad.  

A glimpse at life-saving vaccines
A glimpse at life-saving vaccines

Negative stain electron microscopy of the two novel vaccine technologies: messenger RNA and adenoviral vectors. mRNA is delivered to cells tightly packed in the lipid nanoparticles shown in the first image. By contrast, adenoviruses in the second image have symmetrical shells, inside of which resides the DNA that encodes parts of the SARS-CoV-2 virus.

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Lights on!
Lights on!

Digital rendering overlaid on a scanning transmission electron microscopy image of a cell. By Giulia Angheluță.

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Brain map
Brain map

Digital reconstruction of a sagittal brain section, as observed by confocal laser scanning microscopy

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A glimpse at life-saving vaccines
A glimpse at life-saving vaccines

Negative stain electron microscopy of the two novel vaccine technologies: messenger RNA and adenoviral vectors. mRNA is delivered to cells tightly packed in the lipid nanoparticles shown in the first image. By contrast, adenoviruses in the second image have symmetrical shells, inside of which resides the DNA that encodes parts of the SARS-CoV-2 virus.

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